Raws li thoob ntiaj teb cov kev rog rog nce ntxiv, cov kws tshawb fawb tab tom nrhiav mus tshaj li kev noj zaub mov thiab kev tawm dag zog los tshawb txog cov txheej txheem lom neeg tswj hwm qhov hnyav. Thaum lub neej noj qab nyob zoo tseem yog lub hauv paus ntawm kev tswj qhov hnyav, kev nce qib hauv molecular biology qhia tias qee cov enzymes koom nrog hauv cellular metabolism yuav dhau los ua cov hom phiaj kho mob tshiab. Ntawm cov chaw uas tshwm sim no, nicotinamide N-methyltransferase (NNMT) tau txais kev saib xyuas zoo vim tias nws lub luag haujlwm tseem ceeb hauv kev sib npaug ntawm lub zog, kev cia roj, thiab kev noj qab haus huv hauv metabolic.
Txawm hais tias kev tshawb fawb tseem nyob rau theem pib, cov kws tshawb fawb ntseeg tias kev nkag siab tias NNMT cuam tshuam li cas rau cov metabolism tuaj yeem pab txhim kho tom ntej -kev kho mob rau kev rog rog, metabolic syndrome, thiab lwm yam kab mob.
Vim li cas Kev Tshawb Fawb Kev Noj Qab Haus Huv tsis txwv rau Calories
Kev rog rog yog ib hom kab mob metabolic uas cuam tshuam los ntawm ntau yam, suav nrog cov noob caj noob ces, cov tshuaj hormones, ib puag ncig, kev ua neej nyob, thiab kev qhia ntawm tes. Raws li Lub Koom Haum Ntiaj Teb Kev Noj Qab Haus Huv (WHO), cov neeg rog rog hauv ntiaj teb tau nce ntau dua ob npaug hauv peb lub xyoo dhau los, ua rau muaj kev pheej hmoo ntawm cov kab mob plawv, ntshav qab zib hom 2, kab mob siab rog, thiab qee yam qog noj ntshav.
Thaum txo qis calorie kom tsawg thiab ua kom lub cev ua si tseem yog cov tswv yim tseem ceeb, cov kws tshawb fawb tau pom qhov sib txawv tseem ceeb hauv kev ua haujlwm metabolic ntawm tib neeg. Qhov no tau ua rau cov kws tshawb fawb tshawb xyuas seb cov enzymes tshwj xeeb tswj lub cev muaj peev xwm khaws cia thiab hlawv lub zog. Ib qho enzyme uas tau txais txiaj ntsig tseem ceeb ntawm kev tshawb fawb yog NNMT, uas tau nthuav tawm hauv cov ntaub so ntswg adipose thiab lub siab.
Nkag siab lub luag haujlwm ntawm NNMT
NNMT hloov ib pawg methyl los ntawm S-adenosylmethionine (SAM) mus rau nicotinamide, tsim 1-methylnicotinamide (MNA). Qhov no zoo li yooj yim biochemical cov tshuaj tiv thaiv cuam tshuam rau ob peb txoj hauv kev tseem ceeb hauv metabolic.
Cov kws tshawb fawb tau pom tias kev ua haujlwm siab NNMT tuaj yeem cuam tshuam cov cellular NAD⁺ metabolism, kev siv hluav taws xob, kev rog rog, kev ua haujlwm mitochondrial, kev tswj hwm epigenetic, thiab insulin rhiab heev.
Vim tias NAD⁺ ua lub luag haujlwm tseem ceeb hauv kev tsim hluav taws xob mitochondrial, cov kws tshawb fawb tab tom tshawb nrhiav seb puas txo qis NNMT kev ua haujlwm siab tuaj yeem pab txhim kho kev ua haujlwm ntawm metabolic.
NAD⁺ (nicotinamide adenine dinucleotide) yog ib coenzyme uas muaj nyob hauv txhua lub hlwb. Nws yog qhov tseem ceeb rau kev hloov cov as-ham rau hauv lub zog siv tau thiab txhawb nqa ntau pua cov tshuaj tiv thaiv enzymatic koom nrog hauv kev kho cell thiab kev ua haujlwm mitochondrial. Txo NAD⁺ muaj peev xwm tuaj yeem txo cov metabolism hauv kev ua haujlwm, uas ua rau muaj hnub nyoog - cuam tshuam txog kev ua haujlwm metabolic. Lub koom haum no tau ua rau cov kws tshawb fawb los tshawb xyuas cov enzymes uas tswj cov nicotinamide metabolism, suav nrog NNMT.
Kev Tshawb Fawb Txog Kev Tshawb Fawb Txog Kev Tshawb Fawb NNMT
Txhawm rau kom nkag siab zoo dua NNMT cov khoom siv roj ntsha, cov kws tshawb fawb tau tsim ntau yam kev sim tshuaj uas tuaj yeem xaiv cov enzyme hauv kev kuaj mob. Ib qho kev sib xyaw uas nquag siv hauv kev tshawb fawb txog kev ua haujlwm metabolic yog 5-amino-1MQ. Nws yog ib qho kev tshawb nrhiav me me-molecule NNMT inhibitor tsim los rau kev tshawb fawb hauv chav kuaj es tsis yog siv tshuaj kho mob.
Cov kws tshawb fawb siv cov tshuaj no los tshawb xyuas seb NNMT inhibition cuam tshuam li cas: cov ntaub so ntswg adipose metabolism, cellular NAD⁺ muaj, mitochondrial kev ua, lipid metabolism, kev siv hluav taws xob, thiab cov tshuaj insulin.
Ntau qhov kev tshawb fawb tsiaj tau txuas nrog kev sim NNMT inhibition kom txo cov rog thiab txhim kho cov metabolism, tsis muaj kev hloov pauv tseem ceeb hauv kev noj zaub mov. Cov kev tshawb pom no qhia tias kev tsom mus rau cov metabolism hauv cellular, tsis yog tsuas yog txo qis qab los noj mov, tuaj yeem ntxiv kev kho mob rog. Tam sim no, 5-amino-1MQ tseem yog ib qho kev sim tshuaj siv feem ntau hauv chav kuaj thiab kev tshawb fawb.
NNMT Puas cuam tshuam Lipid Metabolism li cas?
Cov kws tshawb fawb tau npaj ntau lub tswv yim uas NNMT inhibition tuaj yeem cuam tshuam rau lub cev muaj pes tsawg leeg.
Txhawb Cellular Zog Ntau Lawm
NNMT inhibition, los ntawm kev khaws cia nicotinamide rau NAD⁺ synthesis, tuaj yeem txhim kho mitochondrial zog tsim, ua rau cov hlwb siv cov as-ham zoo dua.
Txhim kho lipid siv
Cov kev tshawb fawb soj ntsuam pom tau hais tias qis dua NNMT kev ua haujlwm yuav txhawb kom lub cev siv cov roj khaws cia ua lub zog, tsis yog khaws cov ntaub so ntswg adipose ntxiv.
Txhim kho Metabolic Flexibility
Kev noj qab haus huv metabolism yuav tsum muaj peev xwm hloov tau zoo ntawm cov carbohydrates thiab cov rog raws li lub zog xav tau. Cov kws tshawb fawb ntseeg tias NNMT txoj cai tuaj yeem cuam tshuam qhov kev hloov pauv hauv metabolic.
Txhim kho cov tshuaj insulin secretion
Qee qhov kev tshawb fawb hauv tsev kho mob tau pom tias muaj kev txhim kho cov piam thaj hauv cov ntshav tom qab NNMT inhibition, qhia tias NNMT tuaj yeem cuam tshuam nrog cov kab mob metabolic cuam tshuam nrog insulin tsis kam. Cov txheej txheem no tseem nyob rau hauv kev tshawb nrhiav thiab yuav tsum tsis txhob muab txhais raws li kev tsim kho kev ua tau zoo. Cov Kev Siv Muaj Peev Xwm Tshaj Li Kev Tswj Xyuas Qhov hnyav: Vim tias NNMT koom nrog ntau txoj hauv kev lom neeg, cov kws tshawb fawb tab tom tshawb nrhiav nws lub luag haujlwm tseem ceeb hauv kev noj qab haus huv tshaj li kev rog.
Cov kev tshawb fawb tam sim no muaj xws li: hom 2 mob ntshav qab zib mellitus, cov kab mob metabolic, tsis yog - kab mob cawv fatty siab (NAFLD), kev laus noj qab haus huv, mitochondrial dysfunction, thiab kab mob plawv metabolic. Cov txiaj ntsig ntxov tau txhawb nqa, nrog cov pov thawj feem ntau tam sim no tau los ntawm kev sim thiab kev tshawb fawb tsiaj.
Cov kev sib tw hauv NNMT Kev Tshawb Fawb
Zoo li ntau lub hom phiaj kho mob, NNMT nthuav qhia ob qho tib si hauv kev thiab cov lus nug tsis teb.
Cov kws tshawb fawb txuas ntxiv mus tshawb txog qhov ntev -kev nyab xeeb ntawm NNMT inhibitors, cov tshuaj kho kom tsim nyog, cov ntaub so ntswg- cov teebmeem tshwj xeeb, muaj peev xwm cuam tshuam nrog lwm cov txheej txheem metabolic, thiab cov tib neeg cov caj ces sib txawv uas cuam tshuam rau kev kho mob. Loj - ntsuas qhov ntsuas qhov ntsuas qhov ntsuas qhov ntsuas yog qhov tseem ceeb ua ntej NNMT- cov kev kho mob tau muab tso rau hauv cov ntawv thov kev kho mob niaj hnub. Kev tshawb fawb txog kev rog rog yog hloov los ntawm kev kho mob thoob ntiaj teb mus rau kev cuam tshuam txog kev lom neeg. Cov kws tshawb fawb tsis yog tsuas yog tsom rau kev txwv calorie, tab sis tau mob siab rau kev nkag siab txog cov tes hauj lwm molecular uas tswj hwm lub zog homeostasis. NNMT yog ib qho piv txwv zoo ntawm qhov kev taw qhia tshiab no. Los ntawm kev kawm cov enzymes uas tswj cov cellular metabolism, cov kws tshawb fawb vam tias yuav nrhiav kev kho mob uas tuaj yeem pab txhawb kev ua neej nyob thiab txhim kho kev noj qab haus huv ntev - lub sij hawm metabolic. Kev tshawb nrhiav cov tebchaw xws li 5-amino-1MQ muab cov cuab yeej tseem ceeb rau kev nkag siab txog cov txheej txheem no.
Raws li cov kws tshawb nrhiav kev nkag siab txog tib neeg cov metabolism hauv kev sib sib zog nqus, kev tshawb nrhiav cov tswv yim tswj qhov hnyav dua kuj tseem nce ntxiv. Enzymes xws li NNMT tab tom qhib txoj hauv kev tshiab rau kev tshawb nrhiav seb lub cev tswj hwm cov roj cia, kev siv hluav taws xob, thiab kev noj qab haus huv ntawm tes.
Txawm tias muaj ntau yam tsis paub, kev tshawb fawb tam sim no qhia tias kev tsom mus rau txoj hauv kev metabolic- dua li tsuas yog txo qis calorie kom tsawg- tej zaum yuav yog ib feem tseem ceeb ntawm kev kho mob rog yav tom ntej. Raws li kev tshawb fawb soj ntsuam tau ua tiav, cov kws tshawb fawb vam tias cov kev tshawb pom no yuav pab txhim kho kev nyab xeeb, kev kho tus kheej ntau dua rau cov kab mob metabolic thaum txhim kho lub sijhawm ntev - kev noj qab haus huv.