Pharmaceutical hmoov NNMTi

Cov qauv siab · Traceability · Scalability

Thov hu rau Xi'an Sonwu Biotech Co., Ltd. rau txhua yam khoom koj xav tau.

Xa lus nug tam sim no

Pharmaceutical hmoov NNMTiyog ib qho tseem ceeb metabolic enzyme nyob rau hauv tib neeg lub cev, feem ntau koom nrog hauv nicotinamide (Vitamin B3) - cuam tshuam cov txheej txheem metabolic, thiab tau qhia nyob rau hauv cov ntaub so ntswg adipose, siab, thiab qee cov ntaub so ntswg metabolically.

Cov kev tshawb fawb tau pom tias NNMT ua lub luag haujlwm tseem ceeb hauv kev tswj hwm lub zog metabolism hauv tib neeg lub cev. Kev ua haujlwm NNMT ntau dhau tuaj yeem cuam tshuam nrog kev cia cov roj ntau ntxiv, hloov pauv kev siv hluav taws xob ua haujlwm, thiab kev tsis txaus ntawm cov metabolism. Yog li, cov kws tshawb fawb tau hais tias inhibiting NNMT kev ua los ntawm cov molecules tshwj xeeb tuaj yeem hloov pauv cov qauv siv hluav taws xob ntawm tes. Molecules siv los kawm cov kev cai ntawm NNMT kev ua si yog hu ua NNMTi, uas sawv cev rau Nicotinamide N-methyltransferase inhibitor (NNMT inhibitor).

Tam sim no, 5-amino-1MQ yog ib qho ntawm feem ntau tau hais NNMTi molecules hauv kev tshawb fawb.5-Amino-1MQ (5-amino-1-methylquinolinium) yog ib qho kev sim, xaiv me me molecule inhibitor ntawm cov enzyme nicotinamide N-methyltransferase (NNMT).Yog tias koj txaus siab rau cov khoom lag luam, thov hu rau TIM. Xi'an Sonwu Biotech Co., Ltd.

Xi'an Sonwu Biotech Co., Ltd yog peptide raw khoom muag nrog peptide thev naus laus zis ntawm nws cov tub ntxhais thiab kev lag luam thoob ntiaj teb kev taw qhia. Xi'an Sonwu tshwj xeeb hauv R & D, ntau lawm, thiab thoob ntiaj teb muab cov khoom siv peptides thiab polypeptide raw cov ntaub ntawv, ua haujlwm rau ntau qhov chaw xws li cov leeg tsim, kev zoo nkauj, plaub hau loj hlob, tswj qhov hnyav, nootropics thiab cov khoom siv tshuaj raw khoom.

Xi'an Sonwu cov khoom tau siv dav hauv R & D thiab kev lag luam kev lag luam ntawm cov neeg siv khoom thoob ntiaj teb.Raws li qhov no, Xi'an Sonwu tau txais kev tawm tswv yim ntau ntawm Sonwu cov khoom. Yog li ntawd, yog tias koj xav tau, thov hu rau Xi'an Sonwu.

Xi'an Sonwu tsis tsuas yog muab cov kev pabcuam loj - teev ntau lawm tab sis kuj tseem tuaj yeem muab cov qauv pob khoom rau cov neeg siv khoom ua ntej.

Xi'an Sonwu tsis tsuas yog muab NNMTI hmoov thiab tshuaj ntsiav, tab sis kuj kho cov khoom raws li cov neeg siv khoom xav tau. Tsis tas li ntawd, Sonwu muab cov kev pabcuam ntim khoom, rov ntim khoom raws li cov neeg siv khoom xav tau.

Yog li txhua tus neeg siv khoom tuaj yeem kho pob lawv xav tau. Thiab cov khoom hauv qab no tuaj yeem muab tau.

1.Customized capsule plhaub (loj, xim, khoom)

2.Customized fwj (loj, xim, khoom, style)

3.Customized ntim (lub tshuab nqus tsev ntawv ntim, lub thawv, nruas)

4.Customized daim ntawv lo (xim zaj duab xis, matte zaj duab xis, daim npog qhov muag)

1. Muaj txiaj ntsig zoo txo ​​cov rog thaum khaws cov leeg nqaij. Tsis zoo li cov khoom lag luam poob phaus uas tso siab rau kev noj qab haus huv los yog kev txhawb nqa thermogenesis,Pharmaceutical hmoov NNMTiua tiav cov rog txo los ntawm kev txhim kho cellular metabolism. Qhov kom zoo dua no txawv nws los ntawm feem ntau cov khoom poob phaus, ua rau nws tshwj xeeb tshaj yog haum rau cov tib neeg uas xav tau "kev tswj hwm lub cev rog + kev txuag cov leeg," xws li cov neeg ncaws pob thiab cov neeg nyiam kev noj qab haus huv. Tsis tas li ntawd, nws tuaj yeem txo cov roj cholesterol thiab cov ntshav qab zib hauv cov ntshav, ntxiv dag zog rau kev noj qab haus huv metabolic.

2. Txhim kho Insulin Resistance thiab pab tswj ntshav qab zib. Cov kev tshawb fawb ua ntej tau pom tias kev ua haujlwm siab ntawm NNMT muaj feem cuam tshuam nrog insulin tsis kam thiab ntshav qab zib hom 2. NNMTI, los ntawm inhibiting NNMT, tuaj yeem ua rau nce qib ntawm NAD⁺, txhim kho insulin rhiab heev, thiab txhawb kev qhia ntawm cov piam thaj thauj khoom GLUT4-GLUT4 feem ntau pom muaj nyob hauv cov leeg pob txha thiab adipocytes, lub luag haujlwm rau kev noj qab haus huv thiab kev siv. Ua kom GLUT4 qhia tau zoo tuaj yeem txo cov ntshav qabzib sai thiab qabzib cov ntshav qabzib, muaj peev xwm muab kev pabcuam txhim kho rau cov mob metabolic thiab hom 2 mob ntshav qab zib.

3. ncua kev laus ntawm tes thiab ua kom lub cev muaj zog. NAD⁺ qib poob qis nrog lub hnub nyoog, ua rau mitochondrial tsis ua haujlwm thiab qeeb cellular metabolism. NNMTI, los ntawm kev khaws cia nicotinamide thiab nce NAD⁺ qib, ua kom txoj hauv kev SIRT1/SIRT3, txhim kho mitochondrial muaj nuj nqi, txo cov cellular oxidative puas, thiab ncua kev laus ntawm cellular. Ib txhij, cov kev tshawb fawb tau pom tias nws tseem tuaj yeem ua rau cov leeg pob txha caj qaum, txhim kho cov leeg nqaij, txhim kho kev ua kom muaj zog, thiab txo cov hnub nyoog- cuam tshuam txog cov leeg nqaij thiab lub zog poob.

4. Kev nyab xeeb me me profile thiab zoo kam rau ua. Tsis zoo li peptide tebchaw, 5-Amino-1MQ, raws li ib tug me me molecule compound, muaj nruab nrab ntawm qhov ncauj bioavailability thiab tuaj yeem noj qhov ncauj li NNMTI hmoov thiab tshuaj ntsiav, ua rau nws yooj yim dua rau siv. Kev ua lag luam tam sim no thiab cov neeg siv tshuaj xyuas pom tau tias muaj kev nyab xeeb zoo, ua rau nws tsim nyog rau kev cuam tshuam mus sij hawm ntev.

1. Vim li cas 5-Amino-1MQ thiab NAD+ txuas?

Txawm hais tias lawv txawv, muaj tseeb muaj kev sib txuas ntawm metabolic ntawm lawv. NNMT enzymes koom nrog hauv cov metabolism ntawm nicotinamide (ib daim ntawv ntawm Vitamin B3), uas yog ib qho tseem ceeb precursor rau NAD + synthesis nyob rau hauv tib neeg lub cev. Thaum NNMT kev ua kom zoo dua qub, ntau nicotinamide tuaj yeem hloov mus rau lwm txoj hauv kev metabolic, yog li txo cov khoom siv raw rau NAD + ntau lawm. Yog li, qee cov kws tshawb fawb ntseeg tias inhibiting NNMT kev ua haujlwm tuaj yeem txhim kho kev ua haujlwm ntawm kev siv nicotinamide thiab, los ntawm kev txuas ntxiv, txhawb kev saib xyuas ntawm intracellular NAD + qib. Vim li no, 5-Amino-1MQ nquag tham hauv kev tshawb fawb ntawm NAD + metabolism. Txawm li cas los xij, nws yog ib qho tseem ceeb los hais txog tias 5-Amino-1MQ tsis ncaj qha hloov mus rau NAD + thiab tsis yog NAD + ntxiv. Nws zoo ib yam li cuam tshuam tsis ncaj rau NAD+-txoj kev lom neeg muaj feem cuam tshuam los ntawm kev cuam tshuam txog kev tswj hwm kev sib txuas hauv lub network metabolic. Qhov kev sib raug zoo no zoo sib xws rau kev sib raug zoo ntawm kev tswj hwm txoj kev thiab tus naj npawb ntawm cov tsheb. NAD + zoo li lub tsheb tiag tiag hauv kev ua haujlwm, thaum 5-Amino-1MQ zoo li cov kev tswj hwm uas ua kom zoo rau kev khiav tsheb. Ob leeg tuaj yeem cuam tshuam tag nrho cov txiaj ntsig, tab sis lawv tsis yog tib lub koom haum.

2. Qhov sib txawv ntawm daim ntawv thov kev taw qhia

NAD+-cov khoom lag luam ntsig txog feem ntau tsom rau kev txhawb nqa lub zog ntawm tes, kev laus noj qab haus huv, thiab kev saib xyuas ntawm mitochondrial muaj nuj nqi. Nyob rau hauv xyoo tas los no, NMN, NR, thiab lwm yam NAD + precursors tau txais kev saib xyuas thoob plaws rau lawv lub peev xwm nce qib NAD + hauv lub cev. Ntau qhov kev tshawb fawb tau pom tias kev tswj hwm qib NAD + txaus yog qhov tseem ceeb rau kev kho DNA, cov lus teb ntawm tes, thiab kev tsim hluav taws xob; Yog li ntawd, NAD + cov tswv yim txhim kho tau nquag siv hauv kev tshawb fawb ntev thiab tiv thaiv - kev tshawb fawb kev laus. 5-Amino-1MQ, ntawm qhov tod tes, tshwm sim ntau zaus hauv kev tshawb fawb txog kev noj qab haus huv thiab lub cev muaj pes tsawg leeg optimization. Cov kev sim tsiaj tau pom tias NNMT inhibition tuaj yeem cuam tshuam nrog kev txhim kho lipid metabolism, nce kev siv zog, thiab txhim kho metabolic yooj. Vim li no, 5-Amino-1MQ tau maj mam dhau los ua cov ntsiab lus kub hauv kev tshawb fawb metabolic. Cov kws tshawb fawb vam tias yuav tshawb nrhiav cov tswv yim kev cuam tshuam metabolic ntau dua los ntawm kev hloov kho NNMT txoj kev taw qhia. Los ntawm kev tshawb fawb pom, NAD + tsom mus rau yuav ua li cas cov hlwb tau txais thiab siv lub zog, thaum 5-Amino-1MQ tsom mus rau yuav ua li cas cov hlwb tswj thiab faib cov peev txheej metabolic. Txawm hais tias ob qho tib si muaj feem cuam tshuam rau kev noj qab haus huv metabolism, lawv lub hom phiaj sib txawv heev.

3. Muaj peev xwm Synergistic tus nqi hauv kev tshawb fawb yav tom ntej

Nrog kev nce qib hauv kev tshawb fawb metabolic, kev tshawb fawb ntau ntxiv yog tsom mus rau kev sib cuam tshuam ntawm cov txheej txheem metabolic. Txij li thaum NNMT kev ua haujlwm txuas nrog kev siv nicotinamide, methylation metabolism, thiab lub zog sib npaug, 5-Amino-1MQ thiab NAD+-cov tswv yim hais txog tej zaum yuav muaj txiaj ntsig kev tshawb fawb. Qee cov kws tshawb fawb tau hais tias kev ua kom zoo dua NNMT kev ua haujlwm thaum tswj kev noj qab haus huv NAD + qib tuaj yeem muab kev txhawb nqa ntau dua rau cellular metabolic homeostasis. Txawm li cas los xij, kev tshawb fawb tam sim no tseem nyob rau theem tshawb nrhiav, thiab ntau cov txheej txheem tseem yuav raug txheeb xyuas. Nyob rau hauv lub neej yav tom ntej, raws li kev soj ntsuam thiab cov ntaub ntawv tshawb fawb ntau ntxiv, peb tuaj yeem cia siab tias yuav nkag siab tob txog lub luag haujlwm ntawm ob lub molecules hauv kev noj qab haus huv kev laus thiab kev tswj hwm metabolic. Rau cov neeg nrhiav kom nkag siab txog kev tshawb fawb txog metabolic, kev nkag siab qhov sib txawv ntawm 5-Amino-1MQ thiab NAD + yog qhov tseem ceeb. Txawm hais tias ob qho tib si cuam tshuam nrog kev tshawb fawb txog kev ua neej nyob niaj hnub thiab kev ua kom zoo ntawm cov metabolism, lawv sawv cev rau txoj hauv kev sib txawv. NAD + yog ib qho tseem ceeb coenzyme hauv cellular zog metabolism, thaum 5-Amino-1MQ yog ib qho kev tshawb fawb tshiab uas tsom rau NNMT. Nws yog qhov tsis raug ua kom tsis meej pem ob qho; Tsuas yog los ntawm kev nkag siab zoo txog lawv cov txheej txheem ntawm kev ua haujlwm tuaj yeem peb nkag siab zoo dua cov kev taw qhia tam sim no ntawm kev tshawb fawb metabolic.

1. Xi'an Sonwu Biotech Co., Ltd. Nws tau tsim ib lub platform ua tiav technology, npog peptide molecular tsim, kev cai synthesis, precision purification, structural identification, thiab zoo tswj.

2. Nws nruj me ntsis ua raws li kev tswj hwm thoob ntiaj teb cov qauv zoo, kom ntseeg tau tias nws cov khoom siv peptide ua tau raws li qhov siab -kawg cov kev xav tau ntawm cov neeg siv khoom txawv teb chaws nyob rau hauv cov ntsiab lus ntawm purity, stability, thiab batch sib xws.

3. Saib mus rau lub neej yav tom ntej, nws yuav txuas ntxiv ua kom tob tob peptide thev naus laus zis tshiab, nthuav dav thoob ntiaj teb kev koom tes sib koom tes, thiab siv zog los ua tus neeg ntseeg siab ntev -lub sij hawm peptide raw khoom tov tus khub rau cov neeg siv khoom thoob ntiaj teb.

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Ntxiv rau kev lees paub cov khoom zoo, lwm qhov tseem ceeb tshaj plaws yog cov neeg tuaj yeem tau txais cov khoom lag luam zoo. Yog li, Xi'an Sonwu muab txhua yam kev xa khoom raws li kev xav tau sib txawv.

1. Cov khoom no haum rau leej twg?

Pharmaceutical hmoov NNMTiyog tsim los rau cov neeg laus uas xav txhawb kev noj qab haus huv metabolism, tswj lub cev muaj pes tsawg leeg, thiab txhawb nqa NAD + qib sib npaug. Lawv zoo tshaj plaws rau:

Cov neeg uas muaj cov metabolism qeeb thiab kev tswj qhov hnyav me me xav tau

Cov neeg nrhiav noj qab nyob zoo rog metabolism txhawb

Cov tib neeg txaus siab rau kev noj qab haus huv ntawm cov kab mob metabolic thiab cellular

2. Nws puas tuaj yeem siv los ntawm cov neeg ntawm txhua lub hnub nyoog?

Rau cov neeg laus siv xwb;

3. Cov kev phiv dab tsi tuaj yeem tshwm sim?

Nws yog feem ntau ua tau zoo - zam ntawm cov tshuaj noj uas pom zoo. Kev mob me me, ib ntus tej zaum yuav muaj xws li:

Mob taub hau

Me ntsis xeev siab los yog digestive tsis xis nyob

Kev pw tsaug zog me ntsis yog tias noj lig hnub

Cov teebmeem no feem ntau txo qis thaum lub cev yoog.

4. Leej twg yuav tsum tsis txhob siv cov khoom no?

Cov khoom no tsis yog npaj rau:

Cov poj niam cev xeeb tub los yog pub niam mis

Cov neeg muaj hnub nyoog qis dua 18 xyoo

Cov neeg uas muaj lub siab lossis lub raum tsis zoo

Cov uas noj tshuaj tsis tau nrog ib tus kws kho mob tham

5. Ntev npaum li cas txog thaum kuv tuaj yeem pom cov txiaj ntsig?

Cov txiaj ntsig sib txawv ntawm tus kheej, kev ua neej, thiab kev sib xws.

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Cim npe nrov: Pharmaceutical hmoov NNMTi, Tuam Tshoj Pharmaceutical hmoov NNMTi manufacturers, lwm tus neeg, Hoobkas