Peptide Bay 94 8862

High Standards · Traceability · Scalability

Thov hu rau Xi'an Sonwu Biotech Co., Ltd. rau txhua yam khoom koj xav tau.

Xa lus nug tam sim no

Peptide bay 94 8862(Finerenone) yog ib qho kev xaiv uas tsis yog steroidal mineralocorticoid receptor antagonist. Nws lub luag haujlwm tseem ceeb yog xaiv antagonize intracellular mineralocorticoid receptors, yog li inhibiting cov txheej txheem pathological uas tau tsav los ntawm kev ua kom tsis zoo receptor. Cov tshuaj no tuaj yeem koom nrog hauv kev tswj hwm txoj hauv kev xws li o thiab fibrosis thiab, rau qee qhov, txo cov lus teb inflammatory thiab kev hloov pauv hauv lub raum thiab cov ntaub so ntswg, yog li txhim kho cov xwm txheej ntawm lub hom phiaj. Piv nrog rau cov tshuaj steroid antagonists, nws muaj ntau dua receptor selectivity thiab qis affinity rau poj niam txiv neej hormone thiab glucocorticoid receptors, uas yuav txo tau tej yam tsis zoo tshwm sim thiab ua rau nws ua hauj lwm ntau lub hom phiaj. Nws feem ntau ua rau ob lub raum thiab cov hlab plawv, pab txhim kho lub raum- cov ntsuas ntsuas, txo qhov kev pheej hmoo ntawm proteinuria, thiab tswj lub raum ua haujlwm ruaj khov. Nyob rau tib lub sijhawm, nws siv cov kev cai tswjfwm ntawm vascular thiab myocardial xeev thiab muaj qee yam kev cia siab rau hauv cov haujlwm uas muaj feem xyuam. Yog tias koj xav paub ntau ntxiv txog bay 94 8862 cov khoom siv hmoov, hu rau Xi'an Sonwu Biotech Co., Ltd.

Xi'an Sonwu Biotech Co., Ltd yog peptide raw khoom muag nrog peptide thev naus laus zis ntawm nws cov tub ntxhais thiab kev lag luam thoob ntiaj teb kev taw qhia. Sonwu tshwj xeeb hauv R & D, ntau lawm, thiab thoob ntiaj teb cov khoom siv peptides thiab polypeptide raw khoom. Sonwu cov khoom siv dav siv thoob plaws ntau thaj chaw, suav nrog cov leeg tsim, kev zoo nkauj thiab tiv thaiv - laus, plaub hau kev noj qab haus huv, tswj qhov hnyav, nootropics, thiab cov khoom siv tshuaj.

Sonwu cov khoom tau siv dav hauv cov neeg siv khoom 'R & D thiab kev lag luam kev lag luam thoob ntiaj teb. Raws li qhov no, Sonwu tau txais kev tawm tswv yim ntau ntawm Sonwu cov khoom. Yog li ntawd, yog tias koj xav tau bay 94 8862 hmoov, thov hu rau Xi'an Sonwu.

Xi'an Sonwu tsis tsuas yog muab cov kev pabcuam loj - teev ntau lawm tab sis kuj tseem tuaj yeem muab cov qauv pob rau cov neeg siv khoom ua ntej

Xi'an Sonwu tsis tsuas yog muab cov khoom siv siab - zooPeptide bay 94 8862tab sis kuj muaj cov khoom customized raws li cov neeg siv khoom xav tau.

Ua ntej, rau cov khoom lag luam customized, cov neeg siv khoom yuav tsum tau muab cov ntaub ntawv xws li cov khoom siv CAS tus lej thiab cov txheej txheem sib txuas. Sonwu yuav pab koj xyuas seb qhov kev hloov kho puas ua tau raws li koj qhov yuav tsum tau ua, lossis Sonwu yuav muab cov lus qhia tshaj lij.

Thib ob, hais txog kev ntim khoom customized, Sonwu cov khoom muaj nyob rau hauv qhov ntim tsawg kawg nkaus ntawm 1g, thiab Sonwu tuaj yeem muab cov ntim ntim raws li cov neeg siv khoom thov.

1. Receptor Antagonism
BAY 94-8862 nthuav tawm cov kev xaiv xaiv receptor- tsom antagonism los ntawm kev khi rau thiab inhibiting mineralocorticoid receptors, yog li cuam tshuam hauv cov teeb liab hloov pauv uas tau tsav los ntawm kev ua kom tsis zoo receptor. Piv nrog rau cov tshuaj tiv thaiv ib txwm muaj, nws muaj kev xaiv ntau dua rau cov mineralocorticoid receptors thiab qis affinity rau lwm cov tshuaj hormones receptors, uas ua rau lub hom phiaj meej dua. Qhov kev txiav txim no pab txo qis tus ntoo khaub lig-receptor influences, txo kev cuam tshuam nrog lub cev endogenous hormone system, thiab txhim kho kev ruaj ntseg thiab kev tswj hwm ntawm nws cov teebmeem rau qee qhov. Los ntawm kev tswj hwm receptor- cov teeb liab sib kho, nws tuaj yeem cuam tshuam rau lub xeev kev ua haujlwm ntawm cov hlwb muaj feem xyuam thiab pab tswj cov txheej txheem hloov pauv ntawm cov teeb liab txawv txav, yog li ua lub luag haujlwm zoo hauv kev tswj cov cellular physiological kev ua ub no thiab cov ntaub so ntswg ua haujlwm ruaj khov. Nws tsim nyog rau cov xwm txheej uas xav tau kev tswj hwm mus sij hawm ntev ntawm txoj kev cuam tshuam.
2. Anti-inflammatory thiab Anti-fibrotic Effects

BAY 94-8862 tuaj yeem koom nrog hauv kev tswj hwm cov lus teb inflammatory thiab cov txheej txheem fibrosis. Nws tuaj yeem txo cov ntaub so ntswg hauv zos thiab tiv thaiv kev tsis sib haum xeeb ntawm cov ntaub so ntswg los ntawm kev hloov kho cov lus qhia ntawm cov neeg kho mob inflammatory thiab cuam tshuam cov kev taw qhia. Nws cov txiaj ntsig zoo sib xws suav nrog txo cov ntaub so ntswg puas hauv cov mob ntev, txhim kho cov qauv ntawm cov ntaub so ntswg hloov pauv, thiab ncua kev loj hlob ntawm fibrosis, yog li tswj cov txheeb ze ruaj khov ntawm cov ntaub so ntswg hauv lub cev. Hais txog kev hloov ntawm cov ntaub so ntswg los ntawm lub sij hawm ntev pathological stimulation, cov tshuaj no muaj peev xwm, rau qee qhov, txo cov teeb meem cuam tshuam, txhim kho cov ntaub so ntswg microenvironment, thiab muaj txiaj ntsig zoo rau kev tswj cov ntaub so ntswg ua haujlwm thiab ua rau kev txhim kho ntawm cov txheej txheem txawv txav. Nws qhia qee qhov kev tswj hwm tus nqi hauv lub raum thiab cov hlab plawv.

3. Dej thiab Electrolyte Metabolism Regulation

BAY 94-8862 koom nrog hauv kev tswj hwm lub cev dej thiab electrolyte metabolism. Nws me ntsis nce cov nqaij mos osmotic siab thiab txhim kho vascular homeostasis los ntawm kev hloov ion thauj thiab kua dej sib npaug. Nws cov txiaj ntsig tseem ceeb suav nrog kev khaws cia kev ua haujlwm ruaj khov ntawm cov hlab ntsha thiab cov ntaub so ntswg cuam tshuam, txo qis cov kab mob uas cov dej thiab electrolyte tsis txaus nyob rau hauv lub cev, thiab muaj kev tswj xyuas tshwj xeeb ntawm kev ua haujlwm endothelial thiab vascular reactivity. Tsis tas li ntawd, qhov sib xyaw no tuaj yeem pab tswj lub cev sab hauv ib puag ncig kev sib npaug, txo cov kev cuam tshuam ntawm metabolic nyob rau hauv cov kab mob pathological ntev mus rau qee qhov, thiab txhim kho cov kev cai ntawm lub raum thiab cov hlab plawv homeostasis, yog li txo qhov kev pheej hmoo ntawm kev ua haujlwm hloov pauv hauv cov kab ke no.

1. Receptor Antagonism Mechanism

BAY 94-8862 yog ib yam khoom uas tsis yog tshuaj steroidal uas nws cov txheej txheem tseem ceeb yog kev xaiv khi ntawm mineralocorticoid receptors. Nws muaj kev sib tw nyob rau hauv endogenous ligand-binding sites, inhibiting receptor activation thiab tom ntej conformational kev hloov, thiab, rau qee qhov, cuam tshuam receptor phosphorylation thiab nuclear translocation. Raws li txoj cai, cov khoom no muaj kev sib raug zoo rau cov mineralocorticoid receptors thiab qis affinity rau glucocorticoid thiab poj niam txiv neej receptors, yog li nthuav tawm qhov zoo receptor selectivity. Tom qab kev tswj hwm receptor, nws tuaj yeem cuam tshuam rau kev khi ntawm cov receptors rau cov cheeb tsam txhawb nqa ntawm cov noob caj noob ces, yog li tswj hwm qib transcriptional thiab teeb liab txoj hauv kev ntawm cov noob no. Piv rau steroidal antagonists, nws cov kev cai ntawm receptor-txog txoj hauv kev yog ntau lub hom phiaj; Thaum inhibiting kev ua kom txawv txav, nws muaj qhov cuam tshuam tsawg dua ntawm cov haujlwm hauv lub cev, yog li ua tiav kev xaiv kev cuam tshuam hauv cov txheej txheem pathological rau qee yam.

2. Anti-inflammatory thiab Anti-fibrotic Mechanisms

BAY 94-8862 tuaj yeem cuam tshuam o-txog txoj hauv kev, xws li NF-κB, los ntawm kev tswj hwm mineralocorticoid receptor signaling, yog li txo cov pro-inflammatory teebmeem ntawm receptor activation ntawm transcription yam thiab hloov lawv cov kev cai ntawm inflammatory gene qhia nyob rau hauv lub cell nucleus. Cov txheej txheem no tswj cov kev qhia ntawm ntau tus neeg kho mob inflammatory thiab tuaj yeem, rau qee qhov, cuam tshuam rau kev nrhiav neeg ua haujlwm ntawm cov hlwb thiab qib ntawm cov lus teb hauv zos. Nyob rau tib lub sijhawm, cov tshuaj no ua rau muaj kev tswj hwm cov teebmeem ntawm oxidative kev nyuaj siab- cov txheej txheem cuam tshuam, cuam tshuam rau reactive oxygen hom tsim thiab cuam tshuam cov teeb liab hloov, yog li koom nrog hauv kev tswj hwm cov lus teb. Zuag qhia tag nrho, nws cov tshuaj tiv thaiv kab mob tso siab rau cov kev tswj hwm kev tswj hwm ntawm cov dej ntws, ua rau tsis muaj zog ua kom tsis muaj zog hauv cov xeev mob ntev los ntawm kev cuam tshuam rau kev ua haujlwm ntawm kev taw qhia, uas yog qhov tseem ceeb rau kev tswj hwm intracellular homeostasis.

3. Metabolic Homeostasis Regulation Mechanism

Los ntawm modulating mineralocorticoid receptor signaling, BAY 94-8862 tuaj yeem cuam tshuam rau fibrosis-txoj kev cuam tshuam, xws li kev hloov pauv kev loj hlob ntawm qhov taw qhia. Tsis tas li ntawd, nws tuaj yeem tswj cov kab mob hauv qab ntawm cov kab mob fibrosis- hais txog cov protein qhia, uas tuaj yeem cuam tshuam rau kev ua kom fibroblast thiab ua haujlwm. Tsis tas li ntawd, los ntawm kev hloov kho qhov sib npaug ntawm matrix ntau lawm thiab degradation, cov tshuaj no tuaj yeem pab tswj cov txheej txheem ntawm matrix metabolism thiab txo cov kev cuam tshuam ntawm cov ntaub so ntswg los ntawm aberrant matrix deposition. Tsis tas li ntawd, nws cuam tshuam rau cov txheej txheem xws li kev hloov pauv ntawm epithelial-mesenchymal, uas pab tswj cov cell phenotype stability. Nws tuaj yeem txo qis qhov kev loj hlob ntawm qhov mob mus rau fibrosis los ntawm kev hloov kho cov receptors sab saud thiab cov kev cuam tshuam, uas yog qhov zoo heev rau kev khaws cov ntaub so ntswg thiab kev ua haujlwm ruaj khov.

Xi'an Sonwu Biotech Co., Ltd. tau tsim ib lub tshuab ua tiav platform npog peptide molecular tsim, kev cai synthesis, precision purification, kev txheeb xyuas cov qauv, thiab kev tswj kom zoo. Ua raws li cov qauv kev tswj hwm zoo thoob ntiaj teb, lub tuam txhab ua kom nws cov khoom siv peptide ua tau raws li qhov siab -kawg raw khoom yuav tsum tau ntawm cov neeg muas zaub txawv teb chaws rau purity, stability, thiab batch sib xws.

Saib mus rau yav tom ntej, Sonwu yuav txuas ntxiv mus tob zuj zus peptide thev naus laus zis tshiab, nthuav Sonwu txoj kev koom tes thoob ntiaj teb, thiab siv zog los ua ib tus neeg ntseeg siab, ntev -lub sij hawm peptide raw khoom tov tus khub rau cov neeg siv khoom thoob ntiaj teb.

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ISO 14001

ISO 22000

 

Ntxiv nrog rau kev ua kom cov khoom zoo, lwm qhov tseem ceeb tshaj plaws yog lav kev xa khoom zoo rau Sonwu cov neeg siv khoom. Yog li ntawd, Xi'an Sonwu muaj ntau yam kev xaiv xa khoom raws li kev xav tau ntau yam.

1. Dab tsi yog qhov sib txawv loj tshaj ntawm BAY 94-8862 thiab cov antagonists zoo tib yam?

BAY 94-8862 muaj ntau dua receptor selectivity, tsis yooj yim khi rau lwm cov tshuaj hormones receptors, tsis tshua muaj kev cuam tshuam lub cev qhov qub hormonal tshuav, muaj cov nyhuv purer, thiab muaj kev pheej hmoo ntawm kev phiv.

2. Puas yog BAY 94-8862 puas cuam tshuam rau kev ua haujlwm ntawm lub cev?

Thaum siv kom raug, feem ntau nws yuav tsis cuam tshuam nrog lub cev lub cev ua haujlwm. Nws tsuas yog inhibits ntau dhau ntawm pathological receptor activation, khaws cia cov receptors 'thawj ua haujlwm hauv kev tswj hwm cov haujlwm ntawm lub cev.

Yog tias koj tab tom nrhiav Bay 94 8862 tus neeg muag khoom hmoov, hu rau Xi'an Sonwu. Nyem rau email, thiab tom qab ntawd koj tau txais siab - zooPeptide bay 94 8862.

Email:sales02@sonwu.com

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