Goralatide hmoov

Goralatide hmoov(generic name: Acetyl-Ser-Asp-Lys-Pro, abbreviated as Ac-SDKP) yog ib qho endogenous tetrapeptide secreted los ntawm cov pob txha pob txha. Nws lub luag haujlwm tseem ceeb hauv lub cev yog los ua tus tswj hwm tsis zoo ntawm cov kab mob hematopoietic qia hlwb thiab tiv thaiv cov ntaub so ntswg fibrosis thiab o. Cov peptide no yog ib txwm tsim nyob rau hauv peb lub cev thiab ua hauj lwm nyob rau hauv ntau txoj kev muaj txiaj ntsig- nws pab tiv thaiv peb cov pob txha thiab cov kab mob hauv nruab nrog cev, thiab tseem pab tiv thaiv cov nqaij mos caws pliav. Feem ntau, nws ua haujlwm los ntawm kev tswj kev loj hlob ntawm tes thiab thaiv txoj kev TGF- / Smad uas tsav fibrosis. Nyob rau tib lub sijhawm, nws tseem nthuav tawm ntau yam kev ua haujlwm tshuaj, suav nrog kev hloov pauv ntawm tes, kev tiv thaiv kab mob plawv, thiab kev tiv thaiv lub raum. Yog tias koj xav paub ntau ntxiv, hu rau Xi'an Sonwu Biotech Co., Ltd.

Xi'an Sonwu Biotech Co., Ltd yog peptide raw khoom muag nrog peptide thev naus laus zis ntawm nws cov tub ntxhais thiab kev lag luam thoob ntiaj teb kev taw qhia. Sonwu tau mob siab rau R & D, tsim khoom, thiab thoob ntiaj teb kev faib tawm ntawm bioactive peptide thiab polypeptide cov khoom xyaw. Sonwu cov khoom lag luam tau siv dav hauv ntau qhov chaw, suav nrog cov leeg tsim, kev zoo nkauj thiab tiv thaiv - laus, plaub hau noj qab haus huv, tswj qhov hnyav, nootropics, thiab cov khoom siv tshuaj.

Sonwu cov khoom ua haujlwm rau cov neeg siv khoom thoob ntiaj teb, txhawb nqa kev tshawb fawb thiab kev tsim kho thiab kev lag luam. Raws li qhov no, Sonwu tau txais kev tawm tswv yim ntau ntawm Sonwu cov khoom. Yog li ntawd, yog tias koj xav tau goralatide, thov hu rau Xi'an Sonwu.

Xi'an Sonwu tsis tsuas yog muab cov kev pabcuam loj - teev ntau lawm tab sis kuj tseem tuaj yeem muab cov qauv pob khoom rau cov neeg siv khoom ua ntej.

Xi'an Sonwu tsis tsuas yog muab cov khoom siab - zoo goralatide, tab sis kuj tuaj yeem kho cov khoom raws li cov neeg siv khoom xav tau. Tsis tas li ntawd, Sonwu tuaj yeem muab cov kev pabcuam ntim khoom, suav nrog cov khoom ntim rov qab raws li cov neeg siv khoom xav tau.

1. Customized fwj (loj, xim, khoom, style)

2. Customized ntim (nqus foil ntim, thawv, nruas)

3. Customized daim ntawv lo (xim zaj duab xis, matte zaj duab xis, kho qhov muag daim npog qhov ncauj)

Cov teebmeem lom ntawm Goralatide tso siab rau ob lub tswv yim tseem ceeb uas lub hom phiaj thiab tswj cov cell proliferation, sib txawv, thiab cov ntaub so ntswg microenvironment homeostasis:

1. Hematopoietic Stem Cell Cycle Arrest: Tiv Thaiv Pob Txha Hematopoietic Function

Goralatide ua raws li lub ntuj "braking factor" nyob rau hauv cov pob txha pob txha microenvironment. Tshwj xeeb thaiv kev hloov pauv ntawm hematopoietic qia / progenitor hlwb (HSPCs) los ntawm G0 / G1 theem mus rau theem S inhibits lawv cov kev loj hlob ntau dhau, tswj cov qia cell quiescent xeev, thiab tiv thaiv hematopoietic qia cell depletion. Nov yog qhov nws ua haujlwm li cas ntawm qib molecular: ua ntej, nws txuas rau receptors ntawm lub hlwb. Tom qab ntawd nws hu rau phosphorylation thiab nuclear translocation ntawm Smad2- qhov tseem ceeb, nws ua rau cov txheej txheem qeeb qeeb. Qhov ntawd, dhau los, nres TGF- /Smad txoj hauv kev los ntawm kev ua rau cov hlwb loj hlob ntau dhau. Thiab nyob rau tib lub sijhawm, nws tso tawm cov teeb liab uas ua rau cov qia hlwb ntau, tsom rau cov uas tsis nquag loj hlob (cov so). Qhov no ua rau qeeb npaum li cas lawv cov DNA luam nws tus kheej thiab ntau npaum li cas lawv faib. Los ntawm kev ua qhov no, nws khaws cov pob txha pob txha lub peev xwm los ua cov qe ntshav, thiab nws ua haujlwm tau zoo thaum cov pob txha pob txha puas lawm, zoo li thaum ib tug neeg hla chemo lossis hluav taws xob.

2. Anti-fibrotic, Anti-inflammatory, thiab cov ntaub so ntswg-Kev Tiv Thaiv Cov Teeb Meem: Kev tswj hwm Extracellular Matrix Metabolism

Cov peptide no yog ib qho tseem ceeb ntawm kev tswj hwm hauv peb lub cev uas pab tiv thaiv fibrosis (cov ntaub so ntswg caws pliav). Nws nres qhov kev loj hlob ntawm fibroblast hlwb hauv cov kabmob xws li lub plawv, ob lub raum, thiab daim siab -cov hlwb uas ua rau cov caws pliav. Los ntawm kev ua li ntawd, nws txo cov collagen buildup thiab qhov ntau ntawm cov khoom ntawm extracellular matrix, zoo halting fibrosis los ntawm cov zuj zus.

Txhawm rau rhuav tshem nws yooj yim dua: nws ua rau lub voj voog loj hlob ntawm cov hlwb fibroblast thiab txo qis cov haujlwm thiab cov collagenases (xws li MMP-2, MMP-9, MMP-13). Nyob rau tib lub sijhawm, nws nce mus rau cov ntaub so ntswg inhibitors ntawm metalloproteinases (TIMP-1, TIMP-2) - cov no pab sib npaug li cas lub cev tawg thiab ua rau cov khoom matrix.

Nyob rau sab saum toj ntawm qhov ntawd, nws thaiv cov cim qhia tias tsav fibrosis, uas yog tsim los ntawm inflammatory cytokines (xws li IL-1 ). Qhov ntawd txhais tau tias nws yooj yim rau cov ntaub so ntswg puas los ntawm cov ntshav siab thiab mob, thiab pab tiv thaiv lub plawv thiab ob lub raum.

3. Metabolic thiab Degradation Pathways

Hauv lub cev, Goralatide feem ntau yog tawg los ntawm lub ntuj enzyme hu ua ACE.

Yog vim li cas thaum cov neeg mob noj cov tshuaj ACE inhibitor - xws li enalapril lossis captopril - qib ntawm Goralatide hauv cov ntshav nce siab.

Qhov kev cuam tshuam no kuj tseem pab piav qhia vim li cas nws txoj kev tiv thaiv ntawm lub plawv thiab cov hlab ntsha tuaj yeem muaj zog dua thaum ua ke nrog cov tshuaj no.

Goralatide hmoovnthuav tawm cov txiaj ntsig tseem ceeb xws li kev tiv thaiv hematopoietic, tiv thaiv -fibrosis, thiab tiv thaiv kab mob plawv lossis raum:

1. Cov pob txha pob txha hematopoietic tiv thaiv, txo kev puas tsuaj los ntawm kev siv hluav taws xob thiab kev siv tshuaj khomob

Raws li cov pob txha pob txha- tiv thaiv peptide, nws tuaj yeem txo cov tshuaj lom rau hematopoietic qia hlwb, txo cov kev cuam tshuam tsis zoo xws li cov pob txha pob txha, leukopenia, lossis thrombocytopenia, thiab ntshav ntshav, ua kom cov pob txha pob txha ua haujlwm, thiab tib lub sijhawm tiv thaiv kev pheej hmoo ntawm hematopoietic qia hlwb los ntawm kev txo qis ntawm cov kab mob hauv nruab nrab ntawm cov kab mob. kab mob.

2. Muaj zog tiv thaiv -fibrotic nyhuv, ncua lub cev tsis ua haujlwm.

Nws tuaj yeem thim rov qab lossis ncua qhov kev loj hlob ntawm lub cev fibrosis hauv cov kab mob xws li myocardial, lub raum, thiab daim siab fibrosis. Nyob rau hauv tus qauv kub siab, nws tuaj yeem tiv thaiv cov cell infiltration, collagen deposition, protein downregulation, thiab proteinuria, tiv thaiv lub raum ua haujlwm. Hauv cov qauv kev raug mob plawv, nws inhibits myocardial fibroblast activation, txo qhov tsim ntawm myocardial caws pliav, thiab txhim kho lub plawv ua haujlwm. Nws kuj tseem muaj peev xwm cuam tshuam txog kev cuam tshuam ntawm pulmonary fibrosis thiab daim siab fibrosis, muab cov kev taw qhia tshiab rau kev kho mob ntawm cov kab mob hauv nruab nrog cev.

3. Dual tiv thaiv rau lub plawv thiab lub raum

Nws muaj cov nyhuv antihypertensive thiab kev tiv thaiv kab mob hauv lub cev: Ntawm ib sab, nws pab tswj cov vascular elasticity los ntawm kev tswj cov kev loj hlob ntawm vascular du leeg hlwb thiab txhim kho vascular remodeling; Ntawm qhov tod tes, nws thaiv lub raum o thiab fibrosis induced los ntawm kub siab thiab ntshav qab zib, txo cov proteinuria thiab glomerulosclerosis, thiab slows kev loj hlob ntawm cov kab mob raum, ua rau nws tshwj xeeb tshaj yog haum rau cov neeg mob raum kab mob plawv.

1. Xi'an Sonwu Biotech Co., Ltd. Ltd tau tsim ib qho kev ua tiav technology platform npog peptide molecular tsim, kev cai synthesis, precision purification, kev txheeb xyuas cov qauv, thiab kev tswj kom zoo. Ua raws li cov qauv kev tswj hwm thoob ntiaj teb zoo, lub tuam txhab xyuas kom meej tias nws cov khoom siv peptide ua tau raws li qib siab - cov khoom siv raw khoom kawg ntawm cov neeg siv khoom txawv teb chaws hais txog purity, stability, thiab batch sib xws.

2. Saib mus rau yav tom ntej, Sonwu yuav txuas ntxiv ua kom tob peptide thev naus laus zis tshiab, nthuav dav Sonwu txoj kev koom tes thoob ntiaj teb, thiab sib zog ua kom muaj kev ntseeg siab ntev ntev -lub sij hawm peptide raw khoom tov tus khub rau cov neeg siv khoom thoob ntiaj teb.

Dhau li lav cov khoom, qhov tseem ceeb tshaj plaws yog cov neeg siv khoom tau txais cov khoom lag luam zoo. Yog li, Xi'an Sonwu muaj ntau yam ntawm cov neeg xa xov tuaj yeem ua tau raws li qhov xav tau sib txawv.

Raws li ib txwm tshwm sim endogenous tetrapeptide nyob rau hauv tib neeg lub cev,Goralatide hmoovua qauv qhia tshwj xeeb tshaj yog kev nyab xeeb profile; Cov kev mob tshwm sim me me thiab tsis tshua muaj, thiab tsis muaj kev cuam tshuam loj heev tau pom:

1. Tej yam tshwm sim

Tej zaum koj yuav ntsib teeb meem plab me me, xws li xeev siab me ntsis lossis mob plab. Cov kev xav no feem ntau dhau mus sai, thiab koj yuav tsis tas siv nws. Yog tias koj tau txhaj tshuaj hauv qab ntawm daim tawv nqaij, qhov chaw tuaj yeem liab me ntsis, o, lossis khaus. Tab sis cov cim no ib txwm ploj mus ntawm lawv tus kheej tsis muaj sijhawm.

Kev kiv taub hau thiab qaug zog: Cov tsos mob no yog koob tshuaj - nyob ntawm thiab tuaj yeem txo tau los ntawm kev txo cov koob tshuaj.

2. Tsis tshua muaj tshwm sim

Kev hloov pauv me me hauv kev tiv thaiv kab mob: Ntev- siv sijhawm ntev ntawm kev noj ntau npaum li cas yuav ua rau muaj kev hloov pauv me ntsis ntawm lub cev tiv thaiv kab mob; Txawm li cas los xij, tsis muaj kev pheej hmoo ntawm kev tiv thaiv kab mob los yog hyperstimulation.

Txij li thaum cov tshuaj no tau tawg hauv lub cev los ntawm ib qho enzyme hu ua ACE, kev noj nws nrog ACE inhibitor cov tshuaj ntshav siab tuaj yeem ua rau lawv cov teebmeem muaj zog me ntsis. Vim li no, nws yog ib lub tswv yim zoo los saib xyuas koj cov ntshav siab thaum siv ob qho tib si.

3. Contraindications thiab precautionsContraindicated nyob rau hauv cov neeg uas muaj ib tug paub ua xua rau peptide Cheebtsam.

Kev siv tam sim no tsis pom zoo rau cov poj niam cev xeeb tub lossis pub niam mis vim cov ntaub ntawv kho mob tsis txaus.

Thaum siv concomitantly nrog ACE inhibitors los yog lwm yam tshuaj antihypertensive, ntshav siab yuav tsum tau saib xyuas kom tsis txhob hypotension.

Hauv cov neeg mob menyuam yaus thiab cov tib neeg uas muaj mob siab lossis lub raum tsis zoo, kev kho tshuaj yuav tsum tau ua raws li tus kws kho mob cov lus qhia.

Yog tias koj xav nrhiav tus neeg muag khoom goralatide, hu rau Xi'an Sonwu. Nyem rau email, thiab tom qab ntawd koj tau txais - cov khoom zoo.

Email:sales02@sonwu.com

Cim npe nrov: Tuam Tshoj goralatide hmoov manufacturers, lwm tus neeg, Hoobkas